HAV903V Cancer therapy
Responsables
Crédits : 5 ECTS
Intervenants
PU/MCU-Praticiens hospitaliers :
N. Houédé, F Barlési, A. Evrard, C Bourgier, D. Azria
PH chargés d’enseignement :
W. Jacot, D. Tosi, J. Ciccolini,
Enseignants chercheurs :
M.A. Poul, F. Mennechet, F. Gattacceca, F. Bernex, J. Ciccolini,
Chercheurs:
S. Roche, C Gongora, JM Pascussi, V. Dardalhon, L. Gros, L. Le Cam, M. Busson, A Constantinou
Industriels :
H Bouchard, N. Guilbaud
Objectives
The goal of this course is to provide a broad understanding of the various aspects of cancer cells sensitivity / resistance to cancer treatments, from the molecular targets of anticancer agents, targeting the cancer cells themselves or cancer microenvironment, to the individual modulation of cancer drugs response and toxicities. The course will review chemotherapy, targeted therapies, immunotherapy and radiotherapy approaches in cancer. In addition, during the Pre‐clinical models practical sessions, experienced experts of the field will illustrate how human cancer can be modeled in the mouse, showing the latest technological developments based on genetically engineered mouse models as well as humanized primary xenograft models.
Description
Format: Conférences 30 h ; session pratique 10 h
Part I : Clinical basis of cancer therapy (3 h)
• Pivotal role of anatomapathology in diagnosis and prognosis of cancer
• Clinical trial methodology in cancerology
Part II : Chemotherapy, hormonotherapy and targeted therapies (10 h)
• Basis and principles of chemotherapy
• Targeted therapy : from hormonotherapy to small molecules inhibitors of tyrosine kinase
• Pharmacodynamics aspects (targets, signal transduction pathways) of drug resistance
• Pharmacogenomics and pharmacokinetics determinants of drug response and toxicity
• Cancer stem cells and drug response
• Improving drug delivery to the tumor: nanoparticles and tumor targeting
Part III : Immunotherapy (9 h)
• Immune response against cancer and tumor microenvironnement
• Antibody based‐immunotherapy against cancer, nanobodies
• NK and T‐cell based cancer immunotherapy
• Dendritic cells and anti‐cancer vaccination
• Antibody Drug Conjugates (ADC), the best of two world ?
Part IV : Radiobiology and radiotherapy (7 h)
• Radiobiology : physics and chemistry of radiation absorption, modes of cell death and cell‐survival curves
• Radiobiology : DNA damage, DNA repair, Cell signaling
• Radiobiology: time, dose, fractionation, repopulation, angiogenesis
• Radiosensitizers and radioprotector
• Biomarkers of hyper‐radiosensitive patients
Part V : Perspectives
• Strategies for new anticancer drug discovery and hit identification
• Clinical assessment and implication of biomarkers identification: from early targeted clinical treatment to daily practice
Part VI : Methodoloy in Cancer Research (8 h)
• Genetically engineered mouse models of human cancers and Humanized models
• Training session on small animal imaging (SPECT‐CT, Bioluminescence)
• Training session on anatomo‐pathological analyses of mouse models
Pré-requis
Basis in cell physiopathology
Modalités de contrôles des connaissances
Écrit 100%
Session 2 : écrit