HAV921V Principles of Cancer Biology
Responsables
Crédits : 5 ECTS
Intervenants
JP Hugnot
S. Ansieau
J. De Vos
D. Gregoire
K. Pantel
A R. Thierry
N. Laguette
C. Panabière
L. Akkari
J. Colinge
U. Hibner
P. Pasero
D. Fisher
V. Pinet
A. Maraver
J. Dejardin
S. Roche
A. Turtoï
Jean-Emmanuel Sarry & Lucille Stuani
L. Stuani
M. Levrero
Objectives
Cancer is a disease that exploits basic principles governing the functions of cells and organisms. Understanding cancer biology requires a highly multidisciplinary approach and is a prerequisite for the conception and future implementation of novel therapies.
The course « Principles of cancer biology » discusses the major concepts of current understanding of tumor initiation, progression and escape from treatment. It is complementary to both the » Cell Fate Plasticity » and to « Cancer Therapy » modules.Courses are given by acknowledged experts in different fields, students are encouraged to interact with speakers, many of whom welcome Cancer Biology students in their laboratories for internships.
Description
Format: Lectures 30 h ; analysis and discussion of articles 10 h
Part I : Basic concepts (8 hrs)
- What is cancer? Hallmarks of cancer
- Oncogenes and tumour suppressors
- Genetic instability and cancer
Part II : Cellular Processes (11 hrs)
- Cell cycle deregulation in cancer/mitosis
- Autophagy: treatment escape
- Epithelial-to-MesenchymalTransition (EMT)
- Cancer metabolism
Part III : Pathophysiological processes (10 hrs)
- Hypoxia, neo-Angiogenesis
- Response to stress
- Infection and cancer
- Microenvironment, Inflammation
Part IV : Plasticity/heterogeneity (11 hrs)
- Tumour initiating cells, plasticity
- Minimal residual disease, circulating cancer cells, liquid biopsy, cancer dormancy
- Inter- and intra-tumoral heterogeneity
- Tumour evolution and progression
Modalités de contrôles des connaissances
Écrit 60%
Contrôle Continu 40%
Session 2 : écrit