HAV904V Cell fate & Plasticity

Responsables

François Fagotto

Alenka Čopič

Crédits : 5 ECTS

Objectives

The objectives are:

i. Provide the basic knowledge on the major signaling pathways and their pleiotropic impacts on cell adhesion and other properties,
ii. Introduce cell adhesion in terms of mechanisms and dynamics in development and cancer,
iii. Present how cells use RNA synthesis and splicing programs to rapidly adapt to new environmental conditions,
iv. Describe protein structures and molecular scaffolds by which cell signaling coordinates proliferation and morphology.

This should give students a general knowledge on the signaling pathways that pertain to multicellularity, and the conceptual tools for a better understanding of the notions proposed by the other UEs of the M2s.

Part of the course is also devoted to tutorials on microscopy in modern cell biology and group works on biostatistics for planning experiments and data interpretation.

Description

Central theme of the course:

From molecules to cells to complex organisms: a Cell Biology perspective

Cellular mechanisms involved in determination, differentiation and function of different cell types

How do cells adhere and move in very regulated ways to build and maintain sophisticated body structures (tissues and organs)

When things go wrong: Tissue-specific pathologies and cancer

When cells get old (senescence)

+ Completing the toolkit of the perfect Cell Biologist:

From basic to highly sophisticated cell and molecular approaches

Critical interpretation of results

Moving beyond simple loss- and gain-of-function experiments

Think “out of the box” to extract biological significance

Modalités de contrôles des connaissances

Écrit 100%

Session 2 : écrit