HAV904V Cell fate & Plasticity


François Fagotto

Philippe Fort

Crédits : 5 ECTS


The objectives are:

i. Provide the basic knowledge on the major signaling pathways and their pleiotropic impacts on cell adhesion and other properties,
ii. Introduce cell adhesion in terms of mechanisms and dynamics in development and cancer,
iii. Present how cells use RNA synthesis and splicing programs to rapidly adapt to new environmental conditions,
iv. Describe protein structures and molecular scaffolds by which cell signaling coordinates proliferation and morphology.

This should give students a general knowledge on the signaling pathways that pertain to multicellularity, and the conceptual tools for a better understanding of the notions proposed by the other UEs of the M2s.

Part of the course is also devoted to tutorials on microscopy in modern cell biology and group works on biostatistics for planning experiments and data interpretation.


The following topics will discussed  for a total of 40h:
Signal Transduction
Adhesion in development & cancer
Cell fate & RNA metabolism
Cell signaling & proliferation
Methodology (biostatistics-digital light microscopy)

Modalités de contrôles des connaissances

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Session 2 : écrit